环状RNA：神经疾病领域的一颗新星。
Circular RNA: a new star in neurological diseases.
作者信息
Li Tao-Ran, Jia Yan-Jie, Wang Qun, Shao Xiao-Qiu, Lv Rui-Juan
机构信息
a Department of Neurology, The First Affiliated Hospital of Zhengzhou University , Zhengzhou University , Zhengzhou , PR. China.
b Department of Neurology, Beijing Tiantan Hospital , Capital Medical University , Beijing , PR. China ; China National Clinical Research Center for Neurological Diseases , Beijing , PR. China.
出版信息
Int J Neurosci. 2017 Aug;127(8):726-734. doi: 10.1080/00207454.2016.1236382. Epub 2016 Oct 5.
Circular RNAs (circRNAs) are novel endogenous non-coding RNAs characterized by the presence of a covalent bond linking the 3' and 5' ends generated by backsplicing. In this review, we summarize a number of the latest theories regarding the biogenesis, properties and functions of circRNAs. Specifically, we focus on the advancing characteristics and functions of circRNAs in the brain and neurological diseases. CircRNAs exhibit the characteristics of species conservation, abundance and tissue/developmental-stage-specific expression in the brain. We also describe the relationship between circRNAs and several neurological diseases and highlight their functions in neurological diseases.
环状RNA（circRNAs）是一类新型的内源性非编码RNA，其特征是存在由反向剪接产生的连接3'和5'末端的共价键。在本综述中，我们总结了一些关于circRNAs的生物发生、特性和功能的最新理论。具体而言，我们重点关注circRNAs在大脑和神经疾病中的进展特征及功能。circRNAs在大脑中表现出物种保守性、丰度以及组织/发育阶段特异性表达的特征。我们还描述了circRNAs与几种神经疾病之间的关系，并强调了它们在神经疾病中的功能。
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