Gaspar Michael P, Gaspar Jonathan P, Kane Patrick M
Bull Hosp Jt Dis (2013). 2016 Sep;74(3):185-92.
Inflammatory bowel diseases (IBD) are chronic immunemediated inflammatory conditions involving the gastrointestinal system with potential to adversely affect the musculoskeletal system as well. The numerous overlapping immunogenic and pathophysiologic disease mechanisms of the gastrointestinal and musculoskeletal systems have led to the concept of the "Joint-Gut Axis," illustrating an intimate link between the two organ systems. A solid understanding of the Joint-Gut Axis is necessary for the rheumatologist as well as the orthopaedic surgeon, as concomitant musculoskeletal disease may impart a profoundly negative impact on the quality of life of patients with IBD. Furthermore, a significant subset of patients initially present with secondary musculoskeletal symptoms resulting from an underlying, undiagnosed IBD. Additional non-inflammatory musculoskeletal sequelae of IBD that are not typically attributed to the Joint-Gut Axis should also be recognized by rheumatologists and orthopaedic surgeons in order that the proper preventative and supportive interdisciplinary management may be employed, maximizing patient outcomes and quality of life.
炎症性肠病（IBD）是累及胃肠道的慢性免疫介导的炎症性疾病，也有可能对肌肉骨骼系统产生不利影响。胃肠道和肌肉骨骼系统众多重叠的免疫原性和病理生理疾病机制导致了“关节-肠道轴”这一概念的产生，它阐明了这两个器官系统之间的密切联系。对于风湿病学家和骨科医生来说，深入了解关节-肠道轴是必要的，因为合并的肌肉骨骼疾病可能会对IBD患者的生活质量产生深远的负面影响。此外，相当一部分患者最初表现为由潜在的、未被诊断的IBD引起的继发性肌肉骨骼症状。风湿病学家和骨科医生也应认识到IBD的其他非炎症性肌肉骨骼后遗症，这些后遗症通常不归因于关节-肠道轴，以便能够采用适当的预防性和支持性跨学科管理方法，最大限度地提高患者的治疗效果和生活质量。
