Cassieri Claudio, Pica Roberta, Avallone Eleonora V, Zippi Maddalena, Crispino Pietro, De Nitto Daniela, Paoluzi Paolo, Brandimarte Giovanni, Lecca Piera Giuseppina, Elisei Walter, Picchio Marcello, Tursi Antonio
*Department of Internal Medicine and Medical Specialties, "Sapienza" University †Division of Internal Medicine and Gastroenterology, "Cristo Re" Hospital, GIOMI Group ‡Division of Gastroenterology, ASL Roma H, Albano Laziale §Division of Surgery, "P. Colombo" Hospital, Velletri, Rome ∥Gastroenterology Service, ASL BAT, Andria, BT, Italy.
J Clin Gastroenterol. 2016 Oct;50 Suppl 1:S33-5. doi: 10.1097/MCG.0000000000000631.
Diverticulosis of the colon is an acquired condition that results from herniation of the mucosa and submucosa through defects in the muscular layer. The true prevalence of colonic diverticulosis is difficult to measure because most individuals are asymptomatic. In particularly, in literature, there are few studies about the prevalence of colonic diverticulosis in patients affected by ulcerative colitis (UC).
To investigate the prevalence of colonic diverticulosis in UC and in adult patients referred in a single center.
Consecutive patients, referred to our institution to undergo a colonoscopy for colorectal cancer screening and/or for UC assessment, between January 1, 2014 and December 31, 2014, were studied.
Six hundred five consecutive patients were studied: 438 (72.4%) due to colorectal cancer screening (group A) and 167 (27.6%) for UC assessment (group B). Prevalence of colonic diverticulosis was higher in group A than group B (27.8% vs. 10.8%, P<0.0001). Female gender in patients with colonic diverticulosis was higher in group A than group B (55.7% vs. 22.2%, P=0.0106). Sigma and left colon was mainly involved in group A than group B (97.6% vs. 66.7%, P=0.0001), whereas in group B the right colon was mainly involved in group B versus group A (22.2% vs. 0.8%, P=0.0009).
Prevalence of colonic diverticulosis was significantly lower in patients with UC than in control group. UC may, therefore, be a protective factor for colonic diverticulosis occurrence.
结肠憩室病是一种后天性疾病，由黏膜和黏膜下层通过肌层缺损处疝出所致。由于大多数人无症状，结肠憩室病的真实患病率难以衡量。特别是在文献中，关于溃疡性结肠炎（UC）患者结肠憩室病患病率的研究很少。
调查UC患者及在单一中心就诊的成年患者中结肠憩室病的患病率。
对2014年1月1日至2014年12月31日期间因结直肠癌筛查和/或UC评估而转诊至我院接受结肠镜检查的连续患者进行研究。
共研究了605例连续患者：438例（72.4%）因结直肠癌筛查（A组），167例（27.6%）因UC评估（B组）。A组结肠憩室病的患病率高于B组（27.8%对10.8%，P<0.0001）。A组结肠憩室病患者中的女性比例高于B组（55.7%对22.2%，P=0.0106）。A组中乙状结肠和左半结肠受累为主，高于B组（97.6%对66.7%，P=0.0001），而B组中右半结肠受累为主，高于A组（22.2%对0.8%，P=0.0009）。
UC患者结肠憩室病的患病率显著低于对照组。因此，UC可能是结肠憩室病发生的一个保护因素。
