Rivera Andrea, Messaoudi Ilhem
Division of Biomedical Sciences, University of California, Riverside , Riverside, California 92521, United States.
ACS Infect Dis. 2015 May 8;1(5):186-97. doi: 10.1021/id5000426. Epub 2015 Mar 30.
The filoviruses, Ebola virus (EBOV) and Marburg virus (MARV), are among the deadliest viruses that cause disease in humans, with reported case fatality rates of up to 90% in some outbreaks. The high virulence of EBOV and MARV is largely attributed to the ability of these viruses to interfere with the host immune response. Currently, there are no approved vaccines or postexposure therapeutics, and treatment options for patients infected with EBOV are limited to supportive care. In this review, we discuss mechanisms of EBOV pathogenesis and its ability to subvert host immunity as well as several vaccines and therapeutics with respect to their evaluation in small animal models, nonhuman primates, and human clinical trials.
丝状病毒，埃博拉病毒（EBOV）和马尔堡病毒（MARV），是导致人类疾病的最致命病毒之一，在某些疫情中报告的病死率高达90%。EBOV和MARV的高毒力很大程度上归因于这些病毒干扰宿主免疫反应的能力。目前，尚无获批的疫苗或暴露后治疗方法，感染EBOV患者的治疗选择仅限于支持性护理。在本综述中，我们讨论了EBOV发病机制及其颠覆宿主免疫的能力，以及几种疫苗和治疗方法在小动物模型、非人灵长类动物和人类临床试验中的评估情况。
