State Key Laboratory of Agricultural Microbiology, College of Science, Huazhong Agricultural University, Wuhan 430070, PR China.
State Key Laboratory of Agricultural Microbiology, College of Science, Huazhong Agricultural University, Wuhan 430070, PR China.
Mater Sci Eng C Mater Biol Appl. 2020 Jul;112:110924. doi: 10.1016/j.msec.2020.110924. Epub 2020 Apr 6.
Research on highly effective antiviral drugs is essential for preventing the spread of infections and reducing losses. Recently, many functional nanoparticles have been shown to possess remarkable antiviral ability, such as quantum dots, gold and silver nanoparticles, nanoclusters, carbon dots, graphene oxide, silicon materials, polymers and dendrimers. Despite their difference in antiviral mechanism and inhibition efficacy, these functional nanoparticles-based structures have unique features as potential antiviral candidates. In this topical review, we highlight the antiviral efficacy and mechanism of these nanoparticles. Specifically, we introduce various methods for analyzing the viricidal activity of functional nanoparticles and the latest advances in antiviral functional nanoparticles. Furthermore, we systematically describe the advantages and disadvantages of these functional nanoparticles in viricidal applications. Finally, we discuss the challenges and prospects of antiviral nanostructures. This topic review covers 132 papers and will enrich our knowledge about the antiviral efficacy and mechanism of various functional nanoparticles.
高效抗病毒药物的研究对于防止感染传播和减少损失至关重要。最近，许多功能性纳米粒子已被证明具有显著的抗病毒能力，例如量子点、金和银纳米粒子、纳米团簇、碳点、氧化石墨烯、硅材料、聚合物和树枝状大分子。尽管它们的抗病毒机制和抑制效果不同，但这些基于功能性纳米粒子的结构具有独特的特点，是潜在的抗病毒候选物。在本次专题综述中，我们强调了这些纳米粒子的抗病毒功效和机制。具体而言，我们介绍了分析功能性纳米粒子杀病毒活性的各种方法以及抗病毒功能性纳米粒子的最新进展。此外，我们系统地描述了这些功能性纳米粒子在杀病毒应用中的优缺点。最后，我们讨论了抗病毒纳米结构的挑战和前景。本主题综述涵盖了 132 篇论文，将丰富我们对各种功能性纳米粒子抗病毒功效和机制的认识。
