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[血管性慢性腿部溃疡之前何时该担忧?]

[When to worry about before a vascular chronic leg ulcer?].

作者信息

Lazareth I

机构信息

Service de médecine vasculaire, groupe hospitalier Paris Saint-Joseph, 185, rue Raymond-Losserand, 75674 Paris cedex 14, France.

出版信息

J Mal Vasc. 2016 Sep;41(5):307-14. doi: 10.1016/j.jmv.2016.07.008. Epub 2016 Sep 9.

DOI:10.1016/j.jmv.2016.07.008
PMID:27622980
Abstract

Leg ulcers are a chronic condition. Healing can be long for venous ulcers and the risk of complications is significant. Infection is the most severe complication and can occur in the form of easily diagnosed acute bacterial dermohypodermitis that generally responds well to antibiotic treatment if given at an appropriate dose or in the form of localized infection that is more difficult to diagnosis. Indeed, no consensus has been reached in the literature on the clinical criteria to retain for the diagnosis of localized infection. Similarly, the most appropriate treatment remains to be established. Local care would be a logical starting point, followed by systemic antibiotics if this approach is unsuccessful. Individual conditions also should be taken into consideration (immunodepression, severe arteriopathy warranting more rapid use of systemic antibiotics). The second most frequent complication is an allergic reaction to a topical agent used for wound care. The rate of sensitivization in patients with leg ulcers is high (60 %), although the rate is declining with modern dressings. No product can be considered perfectly safe for these polysensitized patients. Dermocorticoid therapy can be very effective. Allergology tests are needed. Certain leg ulcers require special care from diagnosis. An arterial origin must be suspected for deep, or necrotic ulcers. Arterial supply must be explored rapidly, followed by a revascularization procedure when necessary. Highly painful superficial extensive necrotic ulcers due to necrotic angiodermitis require hospital care for skin grafts that will control the antiodermitis and provide pain. Carcinoma should be suspected in cases of leg ulcers with an atypical localization exhibiting excessive budding. A biopsy is mandatory for leg ulcers with an unusual course (absence of healing despite well-conducted care).

摘要

腿部溃疡是一种慢性疾病。静脉性溃疡的愈合过程可能漫长,且并发症风险很大。感染是最严重的并发症,可能表现为易于诊断的急性细菌性皮肤皮下组织炎,若给予适当剂量的抗生素治疗,通常疗效良好;也可能表现为更难诊断的局部感染。实际上,关于局部感染诊断应采用的临床标准,文献中尚未达成共识。同样,最合适的治疗方法仍有待确定。局部护理可能是合理的起点,若此方法无效则接着使用全身性抗生素。个体情况也应予以考虑(免疫抑制、严重动脉病需要更快使用全身性抗生素)。第二常见的并发症是对用于伤口护理的局部用药产生过敏反应。腿部溃疡患者的致敏率很高(60%),不过随着现代敷料的使用,这一比例正在下降。对于这些多敏患者,没有哪种产品可被认为是绝对安全的。糖皮质激素疗法可能非常有效。需要进行过敏测试。某些腿部溃疡从诊断起就需要特殊护理。对于深部或坏死性溃疡,必须怀疑其动脉源性。必须迅速探查动脉供应情况,必要时接着进行血管重建手术。因坏死性血管皮炎导致的高度疼痛的浅表广泛性坏死性溃疡需要住院接受皮肤移植治疗,这将控制皮肤炎症并缓解疼痛。对于定位不典型且有过度增生的腿部溃疡病例,应怀疑有癌变。对于病程异常(尽管护理得当仍未愈合)的腿部溃疡,活检是必需的。

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