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葡萄糖代谢:阿尔茨海默病的甜蜜缓解。

Glucose Metabolism: A Sweet Relief of Alzheimer's Disease.

机构信息

Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile; Center for Geroscience, Brain Health and Metabolism, Santiago, Chile; Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile.

Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile; Center for Geroscience, Brain Health and Metabolism, Santiago, Chile; Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile; Buck Institute for Research on Aging, Novato, CA 94945, USA.

出版信息

Curr Biol. 2016 Sep 12;26(17):R806-9. doi: 10.1016/j.cub.2016.07.060.

Abstract

Patients and individuals at risk for Alzheimer's disease show reduced glucose metabolism in the brain. A new study takes advantage of a fly model of Alzheimer's disease to demonstrate that enhancing glucose uptake in neurons has strong neuroprotective effects involving improved proteostasis.

摘要

阿尔茨海默病患者和高危个体的大脑葡萄糖代谢减少。一项新的研究利用阿尔茨海默病的果蝇模型证明,增强神经元中的葡萄糖摄取具有强大的神经保护作用,涉及改善蛋白质稳态。

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