Centro de Envejecimiento y Regeneración (CARE), Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Chile.
Centro de Envejecimiento y Regeneración (CARE), Departamento de Biología Celular y Molecular, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Chile; Center for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia; Centro de Excelencia en Biomedicina de Magallanes(CEBIMA), Universidad de Magallanes, Punta Arenas, Chile.
Neurosci Biobehav Rev. 2017 Sep;80:316-328. doi: 10.1016/j.neubiorev.2017.06.004. Epub 2017 Jun 15.
The brain is an organ that has a high demand for glucose. In the brain, glucose is predominantly used in energy production, with almost 70% of the energy used by neurons. The importance of the energy requirement in neurons is clearly demonstrated by the fact that all neurodegenerative disorders exhibit a critical metabolic impairment that includes decreased glucose uptake/utilization and decreased mitochondrial activity, with a consequent diminution in ATP production. In fact, in Alzheimer's disease, the measurement of the general metabolic rate of the brain has been reported to be an accurate tool for diagnosis. Additionally, the administration of metabolic activators such as insulin/glucagon-like peptide 1 can improve memory/learning performance. Despite the importance of energy metabolism in the brain, little is known about the cellular pathways involved in the regulation of this process. Several reports postulate a role for Wnt signaling as a general metabolic regulator. Thus, in the present review, we discuss the antecedents that support the relationship between Wnt signaling and energy metabolism in the Alzheimer's disease.
大脑是一个对葡萄糖有高需求的器官。在大脑中，葡萄糖主要用于能量产生，神经元消耗的能量几乎占 70%。神经元对能量的需求非常重要，所有神经退行性疾病都表现出关键的代谢损伤，包括葡萄糖摄取/利用减少和线粒体活性降低，导致 ATP 生成减少。事实上，在阿尔茨海默病中，已经报道了测量大脑的一般代谢率是一种准确的诊断工具。此外，给予代谢激活剂，如胰岛素/胰高血糖素样肽 1，可以改善记忆/学习表现。尽管能量代谢对大脑很重要，但我们对参与调节这一过程的细胞途径知之甚少。有几项报告假设 Wnt 信号作为一般代谢调节剂的作用。因此，在本综述中，我们讨论了支持 Wnt 信号与阿尔茨海默病中能量代谢之间关系的前因。
