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An alternative effector gene at the type 2 diabetes-associated TCF7L2 locus?

作者信息

van de Bunt Martijn

机构信息

Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Old Road, Headington, Oxford, OX3 7LE, UK.

Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.

出版信息

Diabetologia. 2016 Nov;59(11):2292-2294. doi: 10.1007/s00125-016-4103-4. Epub 2016 Sep 14.

DOI:10.1007/s00125-016-4103-4
PMID:27623948
Abstract
摘要

相似文献

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An alternative effector gene at the type 2 diabetes-associated TCF7L2 locus?2型糖尿病相关的TCF7L2基因座上的另一个效应基因?
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2
TCF7L2: the biggest story in diabetes genetics since HLA?TCF7L2:自HLA以来糖尿病遗传学领域最重大的发现?
Diabetologia. 2007 Jan;50(1):1-4. doi: 10.1007/s00125-006-0507-x.
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The TCF7L2 locus and type 1 diabetes.TCF7L2基因座与1型糖尿病
BMC Med Genet. 2007 Aug 3;8:51. doi: 10.1186/1471-2350-8-51.
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The Wnt signaling pathway effector TCF7L2 and type 2 diabetes mellitus.Wnt信号通路效应因子TCF7L2与2型糖尿病
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TCF7L2 and type 2 diabetes--we WNT to know.TCF7L2与2型糖尿病——我们想了解。 (注:原句中“WNT”可能是“want”的拼写错误)
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Translating TCF7L2: from gene to function.翻译TCF7L2:从基因到功能
Diabetologia. 2009 Jul;52(7):1227-30. doi: 10.1007/s00125-009-1356-1. Epub 2009 Apr 22.
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Overlap of genetic susceptibility to type 1 diabetes, type 2 diabetes, and latent autoimmune diabetes in adults.1型糖尿病、2型糖尿病和成人隐匿性自身免疫性糖尿病遗传易感性的重叠。
Curr Diab Rep. 2014;14(11):550. doi: 10.1007/s11892-014-0550-9.
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Analysis of the type 2 diabetes gene, TCF7L2, in 13,795 type 1 diabetes cases and control subjects.对13795例1型糖尿病病例和对照受试者的2型糖尿病基因TCF7L2进行分析。
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Cystic Fibrosis-Related Diabetes (CFRD): Overview of Associated Genetic Factors.囊性纤维化相关糖尿病(CFRD):相关遗传因素概述
Diagnostics (Basel). 2021 Mar 22;11(3):572. doi: 10.3390/diagnostics11030572.
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Diabetes-associated genetic variation in TCF7L2 alters pulsatile insulin secretion in humans.TCF7L2 基因与糖尿病相关的遗传变异改变了人类脉冲式胰岛素分泌。
JCI Insight. 2020 Apr 9;5(7):136136. doi: 10.1172/jci.insight.136136.
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Transcription Factor 7-Like 2 () Gene Polymorphism and Progression From Single to Multiple Autoantibody Positivity in Individuals at Risk for Type 1 Diabetes.

本文引用的文献

1
The type 2 diabetes presumed causal variant within TCF7L2 resides in an element that controls the expression of ACSL5.TCF7L2基因内的2型糖尿病假定致病变异位于一个控制ACSL5表达的元件中。
Diabetologia. 2016 Nov;59(11):2360-2368. doi: 10.1007/s00125-016-4077-2. Epub 2016 Aug 18.
2
The genetic architecture of type 2 diabetes.2型糖尿病的遗传结构
Nature. 2016 Aug 4;536(7614):41-47. doi: 10.1038/nature18642. Epub 2016 Jul 11.
3
Acyl CoA synthetase 5 (ACSL5) ablation in mice increases energy expenditure and insulin sensitivity and delays fat absorption.
转录因子 7 样 2()基因多态性与 1 型糖尿病高危个体中从单一自身抗体阳性向多种自身抗体阳性的进展。
Diabetes Care. 2018 Dec;41(12):2480-2486. doi: 10.2337/dc18-0861. Epub 2018 Oct 1.
4
Genetic Variants Contribute to Phenotypic Heterogeneity of Type 1 Diabetes.遗传变异导致 1 型糖尿病表型异质性。
Diabetes Care. 2018 Feb;41(2):311-317. doi: 10.2337/dc17-0961. Epub 2017 Oct 12.
小鼠体内酰基辅酶A合成酶5(ACSL5)缺失会增加能量消耗、提高胰岛素敏感性并延缓脂肪吸收。
Mol Metab. 2016 Jan 11;5(3):210-220. doi: 10.1016/j.molmet.2016.01.001. eCollection 2016 Mar.
4
Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors.来自人类胰岛的转录本表达数据将2型糖尿病和血糖性状全基因组关联研究中的调控信号与其下游效应器联系起来。
PLoS Genet. 2015 Dec 1;11(12):e1005694. doi: 10.1371/journal.pgen.1005694. eCollection 2015 Dec.
5
FTO Obesity Variant Circuitry and Adipocyte Browning in Humans.人类中的FTO肥胖变体通路与脂肪细胞褐变
N Engl J Med. 2015 Sep 3;373(10):895-907. doi: 10.1056/NEJMoa1502214. Epub 2015 Aug 19.
6
Human genomics. The human transcriptome across tissues and individuals.人类基因组学。跨组织和个体的人类转录组。
Science. 2015 May 8;348(6235):660-5. doi: 10.1126/science.aaa0355.
7
Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity.2 型糖尿病易感性变异对定量血糖特征的影响揭示了机制异质性。
Diabetes. 2014 Jun;63(6):2158-71. doi: 10.2337/db13-0949. Epub 2013 Dec 2.
8
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.国际小鼠表型分析联盟网站门户,是用于获取基因敲除小鼠及其相关表型数据的统一入口。
Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9. doi: 10.1093/nar/gkt977. Epub 2013 Nov 4.
9
Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand.糖尿病风险基因和 Wnt 效应物 Tcf7l2/TCF4 控制肝脏对围产期和成年代谢需求的反应。
Cell. 2012 Dec 21;151(7):1595-607. doi: 10.1016/j.cell.2012.10.053.
10
Reduced insulin exocytosis in human pancreatic β-cells with gene variants linked to type 2 diabetes.与 2 型糖尿病相关的基因变异会导致人胰腺β细胞胰岛素胞吐作用减少。
Diabetes. 2012 Jul;61(7):1726-33. doi: 10.2337/db11-1516. Epub 2012 Apr 9.