European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK, Medical Research Council Harwell (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire OX11 0RD, UK and Mouse Informatics Group, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9. doi: 10.1093/nar/gkt977. Epub 2013 Nov 4.
The International Mouse Phenotyping Consortium (IMPC) web portal (http://www.mousephenotype.org) provides the biomedical community with a unified point of access to mutant mice and rich collection of related emerging and existing mouse phenotype data. IMPC mouse clinics worldwide follow rigorous highly structured and standardized protocols for the experimentation, collection and dissemination of data. Dedicated 'data wranglers' work with each phenotyping center to collate data and perform quality control of data. An automated statistical analysis pipeline has been developed to identify knockout strains with a significant change in the phenotype parameters. Annotation with biomedical ontologies allows biologists and clinicians to easily find mouse strains with phenotypic traits relevant to their research. Data integration with other resources will provide insights into mammalian gene function and human disease. As phenotype data become available for every gene in the mouse, the IMPC web portal will become an invaluable tool for researchers studying the genetic contributions of genes to human diseases.
国际小鼠表型分析联盟（IMPC）的门户网站（http://www.mousephenotype.org）为生物医学领域的研究人员提供了一个统一的途径，方便他们获取突变小鼠和丰富的相关新兴和现有的小鼠表型数据。全球范围内的 IMPC 小鼠临床研究遵循严格的、高度结构化和标准化的协议，进行实验、数据收集和传播。专门的数据处理人员与每个表型分析中心合作，整理数据并进行数据质量控制。我们开发了一个自动化的统计分析管道，用于识别表型参数发生显著变化的基因敲除株。生物医学本体的注释允许生物学家和临床医生轻松地找到与他们的研究相关的表型特征的小鼠品系。与其他资源的数据整合将有助于深入了解哺乳动物基因功能和人类疾病。随着小鼠中每个基因的表型数据的可用性，IMPC 门户网站将成为研究人员研究基因对人类疾病遗传贡献的宝贵工具。
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