Nahai F, Rand R P, Hester T R, Bostwick J, Jurkiewicz M J
Department of Plastic and Reconstructive Surgery, Emory University, Atlanta, Ga.
Plast Reconstr Surg. 1989 Sep;84(3):434-41. doi: 10.1097/00006534-198909000-00009.
Between 1978 and 1987, 15,595 median sternotomies were performed at Emory University Hospitals. Sternal wound infections developed in 246 patients (1.6 percent). Mediastinitis was present in 211 patients, while superficial infections were detected in the remaining 35 patients. Debridement and muscle or omental flap closure were performed in all instances of mediastinitis, with an overall mortality rate of 5.3 percent. The results of this treatment are reviewed, and the evolution of current therapeutic guidelines is described. When compared with closed-catheter irrigation and open granulation techniques, flap closure is shown to result in a fourfold decrease in mortality, an increased success of primary therapy, and a diminished length of hospitalization following treatment. This evidence supports the conclusion that debridement and flap closure should be considered the primary therapy for patients with poststernotomy mediastinitis.
1978年至1987年间,埃默里大学医院共进行了15595例正中胸骨切开术。246例患者(1.6%)发生了胸骨伤口感染。211例患者发生了纵隔炎,其余35例患者检测到浅表感染。所有纵隔炎病例均进行了清创及肌肉或网膜瓣闭合术,总死亡率为5.3%。本文回顾了该治疗的结果,并描述了当前治疗指南的演变。与闭式导管冲洗和开放肉芽技术相比,瓣闭合术可使死亡率降低四倍,提高初始治疗的成功率,并缩短治疗后的住院时间。这一证据支持以下结论:清创和瓣闭合术应被视为胸骨切开术后纵隔炎患者的主要治疗方法。