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感染性正中胸骨切开术的外科治疗:闭式冲洗与肌瓣治疗对比

Surgical management of infected median sternotomy: closed irrigation vs. muscle flaps.

作者信息

Acinapura A J, Godfrey N, Romita M, Cunningham J, Adams P X, Jacobowitz I J, Rose D M, Nealon T

出版信息

J Cardiovasc Surg (Torino). 1985 Sep-Oct;26(5):443-6.

PMID:4030875
Abstract

Mediastinitis remains a serious complication of median sternotomy which requires prompt and aggressive surgical management. Debridement and closed irrigation has been the conventional mode of treatment. Failure to respond results in open drainage and delayed healing with its associated increased morbidity and mortality. Secondary closure with rectus muscle flaps has been a marked advance in the treatment of these patients. In an attempt to define guidelines for the treatment of mediastinitis complicating median sternotomy, a retrospective review of 2,400 cardiac surgical cases at St. Vincent's Hospital from 1977 through 1982 was performed. There were 25 cases (1%) of mediastinitis. Debridement and closed irrigation was successful in 16 patients (64%) with an average postoperative hospital stay of 19 days. Failure resulted in open drainage in 2 patients (8%) with an average hospital stay of 66 days and debridement and secondary closure by rectus muscle flaps in 7 patients (28%) with an average hospital stay of 28 days. There were no deaths in the entire series. Failure to respond to closed irrigation was not due to delay in diagnosis. The length of time between operation and the first sign of sternal dehiscence did not vary significantly. Sternal dissolution, the presence of anaerobic organisms, large volumes of purulent and necrotic material, however, were responsible for continued mediastinitis and further sternal dehiscence. Open irrigation and delayed closure with muscle flaps should be reserved for these patients and appears to decrease significantly morbidity and length of hospital stay. Surgical debridement and closed irrigation, however, remains the primary method of treatment of the less virulent forms of mediastinitis following median sternotomy.

摘要

纵隔炎仍然是正中开胸手术的一种严重并发症,需要迅速且积极的外科处理。清创术及闭式冲洗一直是传统的治疗方式。若治疗无反应,则需行开放引流,随之而来的是愈合延迟及其相关的发病率和死亡率增加。采用腹直肌瓣二期缝合是这些患者治疗方面的一项显著进展。为了确定正中开胸术后并发纵隔炎的治疗指南,对圣文森特医院1977年至1982年间的2400例心脏手术病例进行了回顾性研究。有25例(1%)发生纵隔炎。清创术及闭式冲洗使16例患者(64%)治疗成功,术后平均住院时间为19天。2例患者(8%)治疗失败,行开放引流,平均住院时间为66天;7例患者(28%)行清创术及腹直肌瓣二期缝合,平均住院时间为28天。整个系列中无死亡病例。对闭式冲洗无反应并非由于诊断延迟。手术至胸骨裂开首个征象出现的时间间隔无显著差异。然而,胸骨溶解、厌氧菌的存在、大量脓性及坏死物质是导致纵隔炎持续及胸骨进一步裂开的原因。对于这些患者应采用开放冲洗及肌瓣延迟缝合,这似乎可显著降低发病率及缩短住院时间。然而,外科清创术及闭式冲洗仍是正中开胸术后毒性较低类型纵隔炎的主要治疗方法。

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