Arbisi P A, Depue R A, Spoont M R, Leon A, Ainsworth B
Dept. of Psychology, University of Minnesota, Minneapolis 55455.
Psychiatry Res. 1989 Jun;28(3):323-34. doi: 10.1016/0165-1781(89)90213-8.
It has recently been proposed that alterations in central dopamine (DA) functional activity may, in part, account for certain behavioral changes observed in seasonal affective disorder (SAD) during the winter. To explore this possibility, a preliminary study of thermoregulatory heat loss to an endogenous heat challenge--a strongly DA-dependent process--was undertaken in groups of four SAD woman and four nonpsychiatric control women across three conditions (winter, after successful phototherapy, and summer). Homeostatic heat loss during recovery from heat challenge in SAD, but not in control, subjects was found to be a significant function of light condition and of clinical state. Thermoregulatory heat loss in SAD subjects was significantly blunted in winter during depression, was similar in efficiency to control subjects after a successful antidepressant response to phototherapy, and tended to be more efficient than controls in summer during a euthymic state. Results raise the possibility that a common effect of phototherapy and summer light conditions is a facilitation of central DA activity in SAD.
最近有人提出，中枢多巴胺（DA）功能活动的改变可能部分解释了冬季季节性情感障碍（SAD）中观察到的某些行为变化。为了探究这种可能性，对一组4名SAD女性和4名非精神科对照女性在三种条件下（冬季、成功进行光疗后、夏季）进行了一项初步研究，该研究针对内源性热刺激的体温调节热损失——这是一个强烈依赖DA的过程。结果发现，SAD受试者（而非对照受试者）在热刺激恢复过程中的稳态热损失是光照条件和临床状态的显著函数。SAD受试者的体温调节热损失在冬季抑郁期间明显减弱，在对光疗产生成功的抗抑郁反应后，其效率与对照受试者相似，在夏季心境正常状态下往往比对照受试者更有效。这些结果增加了一种可能性，即光疗和夏季光照条件的共同作用是促进SAD患者中枢DA的活性。
