Rosenthal N E, Levendosky A A, Skwerer R G, Joseph-Vanderpool J R, Kelly K A, Hardin T, Kasper S, DellaBella P, Wehr T A
Clinical Psychobiology Branchy, National Institutes of Health, Bethesda, MD 20892.
Biol Psychiatry. 1990 Jan 1;27(1):39-50. doi: 10.1016/0006-3223(90)90018-w.
Abnormalities in circadian rhythms of core body temperature have been reported previously in depressed patients. In this study, we compared the temperature rhythms of 10 depressed seasonal affective disorder (SAD) patients with winter depression with those of 12 normal controls and evaluated the effects of bright light on temperature in SAD. Unlike previous studies of depressed patients, the temperature curves of the patients and normal controls during the off-light condition were nearly identical. We found a significant difference in amplitude between the patients in the untreated and light-treated conditions. Although there was no systematic difference in circadian phase across groups or treatment conditions, we present preliminary evidence that suggests that phase-typed subgroups may be present in the population distinguished by their treatment responses.
先前已有报道称抑郁症患者存在核心体温昼夜节律异常。在本研究中，我们比较了10名患有冬季抑郁症的季节性情感障碍（SAD）患者与12名正常对照者的体温节律，并评估了强光对SAD患者体温的影响。与先前对抑郁症患者的研究不同，在熄灯状态下患者和正常对照者的体温曲线几乎相同。我们发现未治疗组和光照治疗组患者的体温振幅存在显著差异。尽管在不同组或治疗条件下昼夜节律相位没有系统性差异，但我们提供的初步证据表明，根据治疗反应区分的人群中可能存在相位类型亚组。
