Böhmer Merle M, Brandl Magdalena, Brandstetter Susanne, Finger Tamara, Fischer Wiebke, Pfeifer Michael, Apfelbacher Christian
a Medical Sociology, Department for Epidemiology and Preventive Medicine , University of Regensburg , Regensburg , Germany.
b Department of Pneumology , Donaustauf Hospital , Donaustauf , Germany.
J Asthma. 2017 Apr;54(3):325-334. doi: 10.1080/02770903.2016.1206563. Epub 2016 Sep 13.
Given a 9% lifetime prevalence of asthma in Germany and the impairment of health-related quality of life (HRQOL) that goes along with it, it is important to understand parameters affecting HRQOL in asthma patients. Objective of this study was therefore to determine factors associated with generic HRQOL in asthma patients.
Data for cross-sectional analyses were obtained from the baseline of an ongoing cohort study.
physician-diagnosed asthma; age ≥18 years; disease duration ≥3 months; no acute psychiatric/neurological disease; sufficient knowledge of German. HRQOL was assessed by the Short Form 12 Health Survey Questionnaire (SF-12), which comprises a physical (PCS-12) and a mental component (MCS-12). Information on a broad range of parameters potentially influencing HRQOL was collected by examining the patients' medical records and via a self-administered questionnaire. Those parameters were of socio-demographic, disease-specific, treatment-related or psychosocial nature. We conducted multivariable linear regression analyses to assess determinants of HRQOL.
In total, 196 asthma patients participated in the study (mean age: 48 years (range: 18-90); 60.2% females). In multivariable analysis, PCS-12 was negatively associated with older age, being female, insufficient disease control, higher number of medications in tablet form and reporting symptoms of depression. MCS-12 was negatively associated with being female, living alone, insufficient disease control, and reporting symptoms of anxiety or depression.
Focusing on disease control and screening for depression and anxiety may be promising approaches to improve HRQOL in adult asthma patients. If a patient shows alarming symptoms of anxiety and/or depression, the patient should then be referred for psychiatric treatment.
鉴于德国哮喘的终生患病率为9%，且随之而来的是健康相关生活质量（HRQOL）受损，了解影响哮喘患者HRQOL的参数非常重要。因此，本研究的目的是确定与哮喘患者一般HRQOL相关的因素。
横断面分析的数据来自一项正在进行的队列研究的基线。
医生诊断为哮喘；年龄≥18岁；病程≥3个月；无急性精神/神经疾病；德语知识充足。HRQOL通过简短健康调查问卷12（SF-12）进行评估，该问卷包括身体成分（PCS-12）和精神成分（MCS-12）。通过检查患者的病历并通过自填问卷收集有关可能影响HRQOL的广泛参数的信息。这些参数具有社会人口统计学、疾病特异性、治疗相关性或心理社会性质。我们进行了多变量线性回归分析以评估HRQOL的决定因素。
共有196名哮喘患者参与了研究（平均年龄：48岁（范围：18-90岁）；60.2%为女性）。在多变量分析中，PCS-12与年龄较大、女性、疾病控制不足、片剂形式的药物数量较多以及报告抑郁症状呈负相关。MCS-12与女性、独居、疾病控制不足以及报告焦虑或抑郁症状呈负相关。
关注疾病控制以及筛查抑郁和焦虑可能是改善成年哮喘患者HRQOL的有前景的方法。如果患者出现焦虑和/或抑郁的警示症状，则应将其转诊接受精神科治疗。
