Kerenidi Theodora, Kazakou Aikaterini P, Lada Martha, Tsilioni Irini, Daniil Zoe, Gourgoulianis Konstantinos I
a Respiratory Medicine Department , University of Thessaly Medical School, University Hospital of Larissa , Larissa , Greece.
Cancer Invest. 2016 Sep 13;34(8):385-92. doi: 10.1080/07357907.2016.1223301.
Osteopontin (OPN) is a multifunctional cytokine involved in carcinogenesis. Serum levels of OPN, vascular endothelial growth factor (VEGF), and matrix metalloproteinase-9 (MMP-9) were measured by ELISA in 90 lung cancer patients. OPN levels were elevated in patients compared to controls (p <.0001). Smokers, patients with worse performance status, and weight loss exhibited higher OPN levels (p =.0012,.00036, and.0003, respectively). Increased OPN levels were associated with worse survival (p =.0018). Finally, OPN levels were positively correlated with both VEGF (p =.0008) and MMP-9 (p <.0001). OPN might serve as a prognostic biomarker, and the positive correlation between OPN and both VEGF and MMP-9 could implicate new insights in tumor angiogenesis.
骨桥蛋白（OPN）是一种参与致癌作用的多功能细胞因子。采用酶联免疫吸附测定法（ELISA）检测了90例肺癌患者血清中骨桥蛋白（OPN）、血管内皮生长因子（VEGF）和基质金属蛋白酶-9（MMP-9）的水平。与对照组相比，患者的OPN水平升高（p <.0001）。吸烟者、体能状态较差的患者以及体重减轻者的OPN水平较高（分别为p =.0012、.00036和.0003）。OPN水平升高与较差的生存率相关（p =.0018）。最后，OPN水平与VEGF（p =.0008）和MMP-9（p <.0001）均呈正相关。OPN可能作为一种预后生物标志物，且OPN与VEGF和MMP-9之间的正相关可能为肿瘤血管生成提供新的见解。
