Conaway Mark R, Wages Nolan A
Division of Translational Research and Applied Statistics, Department of Public Health Sciences, The University of Virginia, 22908, CharlottesvilleVA, U.S.A.
Stat Med. 2017 Jan 30;36(2):254-265. doi: 10.1002/sim.7133. Epub 2016 Sep 14.
We propose a new design for dose finding for cytotoxic agents in two ordered groups of patients. By ordered groups, we mean that prior to the study there is clinical information that would indicate that for a given dose one group would be more susceptible to toxicities than patients in the other group. The designs are evaluated relative to two previously proposed designs for ordered groups over a range of scenarios generated randomly from a family of dose-toxicity curves. Copyright © 2016 John Wiley & Sons, Ltd.
我们提出了一种针对两组有序患者群体中细胞毒性药物剂量探索的新设计。所谓有序群体，是指在研究之前存在临床信息表明，对于给定剂量，一组患者比另一组患者更容易出现毒性反应。在从一系列剂量-毒性曲线随机生成的一系列场景中，将这些设计与之前提出的两种针对有序群体的设计进行了评估比较。版权所有© 2016约翰·威利父子有限公司。
