Kim Eunhye, Hyun Sang-Hwan
Institute for Stem Cell & Regenerative Medicine (ISCRM), Chungbuk National University, Cheongju 28644, Chungbuk, Korea.
Laboratory of Veterinary Embryology and Biotechnology(VETEMBIO), Veterinary Medical Center and Collage of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Chungbuk, Korea.
Int J Mol Sci. 2016 Sep 12;17(9):1533. doi: 10.3390/ijms17091533.
Pigs have great potential to provide preclinical models for human disease in translational research because of their similarities with humans. In this regard, porcine pluripotent cells, which are able to differentiate into cells of all three primary germ layers, might be a suitable animal model for further development of regenerative medicine. Here, we describe the current state of knowledge on apoptosis in pluripotent cells including inner cell mass (ICM), epiblast, embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs). Information is focused on the apoptotic phenomenon in pluripotency, maintenance, and differentiation of pluripotent stem cells and reprogramming of somatic cells in pigs. Additionally, this review examines the multiple roles of apoptosis and summarizes recent progress in porcine pluripotent cells.
由于猪与人类存在相似性，因此在转化研究中，猪具有为人类疾病提供临床前模型的巨大潜力。在这方面，能够分化为所有三个原始胚层细胞的猪多能细胞，可能是再生医学进一步发展的合适动物模型。在这里，我们描述了关于多能细胞（包括内细胞团（ICM）、上胚层、胚胎干细胞（ESC）和诱导多能干细胞（iPSC））凋亡的当前知识状态。信息聚焦于猪多能干细胞在多能性、维持、分化以及体细胞重编程过程中的凋亡现象。此外，本综述探讨了凋亡的多种作用，并总结了猪多能细胞的最新进展。
