Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.
Department of Developmental Biology and Cancer Research, The Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.
Curr Opin Genet Dev. 2017 Oct;46:37-43. doi: 10.1016/j.gde.2017.06.012. Epub 2017 Jun 30.
How the first cell fate decision of an embryo occurs is one of the most fascinating biological questions examined over the last few decades, with numerous in vivo models proposed and many factors tested for their role in the process. In this review, we will primarily focus on the mouse model and discuss the role that transcription factors play during establishment and maintenance of the first lineage segregation in the embryo, towards inner cell mass or trophectoderm. We will also overview recent developments in somatic nuclear reprogramming into induced pluripotent stem cells, the inner cell mass (epiblast) equivalent, and into induced trophoblast stem cells, the trophectoderm equivalent, and discuss potential correspondences between the in vivo and in vitro models.
胚胎中第一个细胞命运决定是过去几十年中研究最引人入胜的生物学问题之一，提出了许多体内模型，并测试了许多因素在该过程中的作用。在这篇综述中，我们将主要关注小鼠模型，并讨论转录因子在胚胎中内细胞团或滋养外胚层的建立和维持过程中所起的作用。我们还将概述体细胞重编程为诱导多能干细胞（内细胞团（上胚层）等效物）和诱导滋养层干细胞（滋养外胚层等效物）的最新进展，并讨论体内和体外模型之间的潜在对应关系。
