HIV-1 核衣壳蛋白-核糖核酸复合物的生命周期
The Life-Cycle of the HIV-1 Gag-RNA Complex.
作者信息
Mailler Elodie, Bernacchi Serena, Marquet Roland, Paillart Jean-Christophe, Vivet-Boudou Valérie, Smyth Redmond P
机构信息
Architecture et Réactivité de l'ARN, Université de Strasbourg, IBMC, CNRS, 15 rue René Descartes, 67084 Strasbourg, France.
出版信息
Viruses. 2016 Sep 10;8(9):248. doi: 10.3390/v8090248.
Human immunodeficiency virus type 1 (HIV-1) replication is a highly regulated process requiring the recruitment of viral and cellular components to the plasma membrane for assembly into infectious particles. This review highlights the recent process of understanding the selection of the genomic RNA (gRNA) by the viral Pr55(Gag) precursor polyprotein, and the processes leading to its incorporation into viral particles.
1型人类免疫缺陷病毒（HIV-1）的复制是一个高度受调控的过程，需要将病毒和细胞成分募集到质膜上，以组装成感染性颗粒。本综述重点介绍了近年来对病毒Pr55（Gag）前体多蛋白选择基因组RNA（gRNA）的过程，以及导致其掺入病毒颗粒的过程的理解。
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