College of Chemistry, Jilin University , 2699 Qianjin Street, Changchun 130012, China.
Org Lett. 2016 Oct 7;18(19):5002-5005. doi: 10.1021/acs.orglett.6b02460. Epub 2016 Sep 14.
The first example of Pd-catalyzed intramolecular C-H addition of indoles bearing cyanohydrin components at the C(3), C(2), and N(1) positions to nitriles is described. A wide range of functionalized partially saturated carbazoles, tetrahydropyrido[1,2-a]indole, and carbazoles can be prepared in good to excellent yields under the optimal conditions. In addition, fused polycyclic indoles with seven- or eight-membered rings can also be formed smoothly.
首例 Pd 催化的吲哚分子内 C-H 加成反应被描述，其中吲哚的 C(3)、C(2)和 N(1)位带有氰醇基团，可以与腈反应。在最佳条件下，可得到一系列官能化的部分饱和的咔唑、四氢吡啶并[1,2-a]吲哚和咔唑，产率良好至优秀。此外，还可以顺利地形成稠合的具有七元或八元环的多环吲哚。
