蛋白质组复杂性以及驱动蛋白质组失衡的因素。
Proteome complexity and the forces that drive proteome imbalance.
作者信息
Harper J Wade, Bennett Eric J
机构信息
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Section of Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093, USA.
出版信息
Nature. 2016 Sep 15;537(7620):328-38. doi: 10.1038/nature19947.
Abstract
The cellular proteome is a complex microcosm of structural and regulatory networks that requires continuous surveillance and modification to meet the dynamic needs of the cell. It is therefore crucial that the protein flux of the cell remains in balance to ensure proper cell function. Genetic alterations that range from chromosome imbalance to oncogene activation can affect the speed, fidelity and capacity of protein biogenesis and degradation systems, which often results in proteome imbalance. An improved understanding of the causes and consequences of proteome imbalance is helping to reveal how these systems can be targeted to treat diseases such as cancer.
摘要
细胞蛋白质组是一个由结构和调控网络组成的复杂微观世界，需要持续的监测和修饰以满足细胞的动态需求。因此，细胞的蛋白质通量保持平衡对于确保细胞正常功能至关重要。从染色体失衡到癌基因激活等基因改变会影响蛋白质生物合成和降解系统的速度、保真度和能力，这常常导致蛋白质组失衡。对蛋白质组失衡的原因和后果有了更深入的了解，有助于揭示如何针对这些系统来治疗癌症等疾病。
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