利用磁共振成像预测直肠癌中的KRAS突变
Prediction of KRAS Mutation in Rectal Cancer Using MRI.
作者信息
Shin Yu Ri, Kim Kyung Ah, Im Soyoung, Hwang Seong Su, Kim Kijun
机构信息
Department of Radiology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Department of Radiology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon-si, Republic of Korea
出版信息
Anticancer Res. 2016 Sep;36(9):4799-804. doi: 10.21873/anticanres.11039.
AIM
The purpose of the study was to investigate imaging predictors of Kirsten-ras (KRAS) mutations using magnetic resonance imaging (MRI) in patients with rectal cancer.
PATIENTS AND METHODS
A total of 275 patients with rectal cancer were enrolled. They underwent pretreatment rectal MRI, and then KRAS mutation evaluation following surgery. Two reviewers assessed diverse MRI findings associated with rectal cancer.
RESULTS
KRAS mutations were detected in 107 (38.9%). KRAS mutations were associated with N stage, gross tumor pattern, axial length of the tumor, and the ratio of the axial to the longitudinal dimensions of the tumor (p=0.0064, p<0.0001, p=0.0003 and p=0.0090). The frequency of KRAS mutations was higher in N2 stage (53.70%), and polypoid tumors (59.09%). Tumors with KRAS mutations exhibited a longer axial length, as well as a larger ratio of the axial to the longitudinal dimensions.
CONCLUSION
KRAS mutations were associated with N stage, a polypoid pattern, axial tumor length, and the ratio of the axial to the longitudinal dimensions of the tumor.
目的
本研究旨在利用磁共振成像（MRI）探究直肠癌患者 Kirsten 鼠肉瘤病毒癌基因（KRAS）突变的影像学预测指标。
患者与方法
共纳入 275 例直肠癌患者。他们在术前接受了直肠 MRI 检查，术后进行了 KRAS 突变评估。两名评估者对与直肠癌相关的多种 MRI 表现进行了评估。
结果
107 例（38.9%）检测到 KRAS 突变。KRAS 突变与 N 分期、大体肿瘤形态、肿瘤轴向长度以及肿瘤轴向与纵向尺寸之比相关（p = 0.0064，p < 0.0001，p = 0.0003 和 p = 0.0090）。KRAS 突变在 N2 期（53.70%）和息肉样肿瘤（59.09%）中发生率更高。发生 KRAS 突变的肿瘤轴向长度更长，轴向与纵向尺寸之比也更大。
结论
KRAS 突变与 N 分期、息肉样形态、肿瘤轴向长度以及肿瘤轴向与纵向尺寸之比相关。
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