Martínez-García Mireya, Hernández-Lemus Enrique
Sociomedical Research Unit, National Institute of Cardiology "Ignacio Chávez", Mexico City, Mexico.
Computational Genomics Division, National Institute of Genomic Medicine (INMEGEN), Mexico City, Mexico.
Front Physiol. 2021 Oct 27;12:709438. doi: 10.3389/fphys.2021.709438. eCollection 2021.
Periodontitis is a common inflammatory disease of infectious origins that often evolves into a chronic condition. Aside from its importance as a stomatologic ailment, chronic periodontitis has gained relevance since it has been shown that it can develop into a systemic condition characterized by unresolved hyper-inflammation, disruption of the innate and adaptive immune system, dysbiosis of the oral, gut and other location's microbiota and other system-wide alterations that may cause, coexist or aggravate other health issues associated to elevated morbi-mortality. The relationships between the infectious, immune, inflammatory, and systemic features of periodontitis and its many related diseases are far from being fully understood and are indeed still debated. However, to date, a large body of evidence on the different biological, clinical, and policy-enabling sources of information, is available. The aim of the present work is to summarize many of these sources of information and contextualize them under a systemic inflammation framework that may set the basis to an integral vision, useful for basic, clinical, and therapeutic goals.
牙周炎是一种常见的起源于感染的炎症性疾病，通常会发展为慢性疾病。除了作为一种口腔疾病的重要性之外，慢性牙周炎的相关性也日益凸显，因为已有研究表明，它可能发展为一种全身性疾病，其特征为炎症持续不消、先天和适应性免疫系统紊乱、口腔、肠道及其他部位的微生物群失调，以及其他可能导致、并存或加重与高病亡率相关的其他健康问题的全身性改变。牙周炎及其众多相关疾病的感染、免疫、炎症和全身特征之间的关系远未得到充分理解，实际上仍存在争议。然而，迄今为止，已有大量来自不同生物学、临床和政策支持方面的信息证据。本研究的目的是总结其中的许多信息来源，并将它们置于一个全身性炎症框架中进行背景分析，这可能为形成一个全面的观点奠定基础，对基础、临床和治疗目标都有用。
