人参在神经退行性疾病中的作用。
Effects of Panax ginseng in Neurodegenerative Diseases.
机构信息
Department of Anatomy, College of Oriental Medicine and Institute of Oriental Medicine, Kyung Hee University, Seoul 130-701, Korea.
出版信息
J Ginseng Res. 2012 Oct;36(4):342-53. doi: 10.5142/jgr.2012.36.4.342.
Abstract
Ginseng, the root of the Panax ginseng, has been a popular and widely-used traditional herbal medicine in Korea, China, and Japan for thousands of years. Now it has become popular as a functional health food and is used globally as a natural medicine. Evidence is accumulating in the literature on the physiological and pharmacological effects of P. ginseng on neurodegenerative diseases. Possible ginseng- or ginsenosides-mediated neuroprotective mechanisms mainly involve maintaining homeostasis, and anti-inflammatory, anti-oxidant, anti-apoptotic, and immune-stimulatory activities. This review considers publications dealing with the various actions of P. ginseng that are indicative of possible neurotherapeutic efficacies in neurodegenerative diseases and neurological disorders such as Parkinson's disease, Alzheimer's disease, Huntington's disease, and amyotrophic lateral sclerosis and multiple sclerosis.
摘要
人参是 Panax ginseng 的根，几千年来一直是韩国、中国和日本广受欢迎的传统草药。现在它已成为一种流行的功能性保健品，并在全球范围内作为天然药物使用。文献中越来越多的证据表明人参对神经退行性疾病具有生理和药理作用。人参或人参皂苷介导的神经保护机制可能主要涉及维持内环境平衡，以及抗炎、抗氧化、抗细胞凋亡和免疫刺激活性。本综述考虑了与人参的各种作用相关的出版物，这些作用表明人参在神经退行性疾病和神经系统疾病（如帕金森病、阿尔茨海默病、亨廷顿病和肌萎缩侧索硬化症和多发性硬化症）中具有潜在的神经治疗功效。
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本文引用的文献
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Gintonin, a ginseng-derived lysophosphatidic acid receptor ligand, attenuates Alzheimer's disease-related neuropathies: involvement of non-amyloidogenic processing.金雀异黄素，一种源自人参的溶血磷脂酸受体配体，可减轻与阿尔茨海默病相关的神经病变：涉及非淀粉样蛋白生成过程。
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