Duhig Kate, Chappell Lucy C, Shennan Andrew H
Women's Health Academic Centre, King's College London, London, UK.
Obstet Med. 2016 Sep;9(3):113-6. doi: 10.1177/1753495X16648495. Epub 2016 May 17.
Oxidative stress is implicated in the pathophysiology of many reproductive complications including infertility, miscarriage, pre-eclampsia, fetal growth restriction and preterm labour. The presence of excess reactive oxygen species can lead to cellular damage of deoxyribonucleic acids, lipids and proteins. Antioxidants protect cells from peroxidation reactions, limiting cellular damage and helping to maintain cellular membrane integrity. There is overwhelming evidence for oxidative stress causing harm in reproduction. However, there is sparse evidence that supplementation with commonly used antioxidants (mostly vitamins C and E) makes any difference in overcoming oxidative stress or reversing disease processes. There may be potential for antioxidant therapy to ameliorate or prevent disease, but this requires a thorough understanding of the mechanism of action and specificity of currently used antioxidants.
氧化应激与许多生殖并发症的病理生理学有关，包括不孕症、流产、先兆子痫、胎儿生长受限和早产。过量活性氧的存在会导致脱氧核糖核酸、脂质和蛋白质的细胞损伤。抗氧化剂可保护细胞免受过氧化反应的影响，限制细胞损伤并有助于维持细胞膜的完整性。有大量证据表明氧化应激会对生殖造成损害。然而，几乎没有证据表明补充常用的抗氧化剂（主要是维生素C和E）在克服氧化应激或逆转疾病进程方面有任何作用。抗氧化剂疗法可能有改善或预防疾病的潜力，但这需要深入了解目前所用抗氧化剂的作用机制和特异性。
