Giri Vishal Prakash, Giri Om Prakash, Khan Farhan Ahmad, Kumar Narendra, Kumar Ajay, Haque Ataul
Assistant Professor, Department of Pharmacology, Teerthanker Mahaveer Medical College and Research Centre , Moradabad, U.P, India .
Professor and Head, Department of Pulmonary Medicine, Darbhanga Medical College and Hospital , Darbhanga, Bihar, India .
J Clin Diagn Res. 2016 Jul;10(7):FC01-4. doi: 10.7860/JCDR/2016/16911.8121. Epub 2016 Jul 1.
Idiopathic Generalized Tonic-Clonic Seizures (GTCS) are frequently encountered in adults. Their successful control is necessary to improve the quality of life of these patients. Valproic acid is a simple branched-chain carboxylic acid and lamotrigine is a phenyltriazine derivative. Opinions differ in regards to their effectiveness in idiopathic GTCS.
To compare the effectiveness of valproic acid and lamotrigine in newly diagnosed adults with idiopathic generalized tonic-clonic seizures.
The present prospective randomized study was conducted on 60 patients suffering from idiopathic GTCS. Thirty patients received valproic acid and rest 30 patients received lamotrigine. All patients were followed regularly monthly for one year for treatment response and adverse effects.
After 12 months follow-up, 76.67% patients taking valproic acid and 56.67% patients taking lamotrigine were seizure-free. Common adverse effects recorded were nausea, dyspepsia, headache and skin rash.
Valproic acid is more effective than lamotrigine as first-line drug in the treatment of adults with newly diagnosed idiopathic generalized tonic-clonic seizures.
特发性全面强直阵挛发作（GTCS）在成人中较为常见。成功控制此类发作对于改善这些患者的生活质量至关重要。丙戊酸是一种简单的支链羧酸，拉莫三嗪是一种苯基三嗪衍生物。关于它们在特发性GTCS中的有效性，存在不同观点。
比较丙戊酸和拉莫三嗪对新诊断的成人特发性全面强直阵挛发作的疗效。
本前瞻性随机研究针对60例特发性GTCS患者进行。30例患者接受丙戊酸治疗，其余30例患者接受拉莫三嗪治疗。所有患者每月定期随访一年，观察治疗反应和不良反应。
随访12个月后，服用丙戊酸的患者中有76.67%无癫痫发作，服用拉莫三嗪的患者中有56.67%无癫痫发作。记录到的常见不良反应有恶心、消化不良、头痛和皮疹。
在治疗新诊断的成人特发性全面强直阵挛发作时，丙戊酸作为一线药物比拉莫三嗪更有效。
