[扩张型心肌病中补体系统的激活]

[Activation of the complement system in dilated cardiomyopathy].

作者信息

Nasonov E L, Samsonov M Iu, Aleksandrova L Z, Masenko V P, Ovtrakht N V

出版信息

Ter Arkh. 1989;61(4):59-63.

Abstract

The levels of anaphylatoxins (C3a, C5a) in blood, components of complements C3 and C4, antibodies to cardiolipin, IgG, IgA, IgM, IgE and circulating immune complexes were measured in 21 patients with dilated and hypertrophic cardiomyopathy (DCMP and HCMP) and in 11 donors. The mean level of C3a in DCMP patients (572 +/- 55 ng/ml) was significantly higher than in HCMP patients (344 +/- 30 ng/ml) and in donors (294 +/- 43 ng/ml) (p less than 0.001). On comparison of C5a concentrations in DCMP patients (2.2 +/- 0.52 ng/ml), HCMP patients (3.3 +/- 1.2 ng/ml) and in donors (1.6 +/- 0.82 ng/ml) no significant differences were found (p greater than 0.05). It has been established that in the group of DCMP patients with thromboembolic complications, the concentrations of C3a (736 +/- 95 ng/ml) were significantly higher than in those without such complications (334 +/- 14 ng/ml) (p less than 0.001). The data obtained permit discussing the role of anaphylatoxins in the development of thromboembolic complications in DCMP patients.

摘要

检测了21例扩张型和肥厚型心肌病（DCMP和HCMP）患者及11名献血者血液中的过敏毒素（C3a、C5a）水平、补体C3和C4成分、抗心磷脂抗体、IgG、IgA、IgM、IgE及循环免疫复合物水平。DCMP患者的C3a平均水平（572±55 ng/ml）显著高于HCMP患者（344±30 ng/ml）和献血者（294±43 ng/ml）（p<0.001）。比较DCMP患者（2.2±0.52 ng/ml）、HCMP患者（3.3±1.2 ng/ml）和献血者（1.6±0.82 ng/ml）的C5a浓度，未发现显著差异（p>0.05）。已确定，在有血栓栓塞并发症的DCMP患者组中，C3a浓度（736±95 ng/ml）显著高于无此类并发症的患者（334±14 ng/ml）（p<0.001）。所获得的数据有助于探讨过敏毒素在DCMP患者血栓栓塞并发症发生中的作用。