[免疫研究在各种形式心肌病中的价值]

[Value of immunological studies in various forms of cardiomyopathy].

作者信息

Iurenev A P, Chumburidze V B, Polianskaia I S, Iazdovskiĭ V V, Krukovskaia Z V

出版信息

Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR. 1987;10(2):101-6.

Abstract

Immunologic status of 97 patients with dilating cardiomyopathy (DCMP) and 52 patients with hypertrophic cardiomyopathy (HCMP) was studied; total amount of T-lymphocytes as well as the amount of T-active lymphocytes and B-lymphocytes in the test of E- and EAC-rosette formation, subpopulations of T-lymphocytes (T mu, T g in the EA-rosette formation reaction were determined. HLA-typing in the microlymphocytes toxic test was performed. It was determined that the amount of B- and T-lymphocytes as well as the amount of T mu- and Tg-lymphocytes in patients with HCMP does not practically differ from that in normal subjects. Antigens 27, DR1 and DR4 were proved to be HLA-markers of HCMP. Reliable decrease in the amount of T mu and Tg cells as well as NK cells in patients with DCMP compared to that in normal subjects and patients with HCMP was observed. The study of HLA-antigens distribution in patients with DCMP revealed greater prevalence of DR1 and DR4 antigens.

摘要

对97例扩张型心肌病（DCMP）患者和52例肥厚型心肌病（HCMP）患者的免疫状态进行了研究；测定了E-玫瑰花结和EAC-玫瑰花结形成试验中T淋巴细胞的总量以及T活性淋巴细胞和B淋巴细胞的数量，确定了T淋巴细胞亚群（EA-玫瑰花结形成反应中的Tμ、Tg）。进行了微量淋巴细胞毒性试验中的HLA分型。结果表明，HCMP患者的B淋巴细胞和T淋巴细胞数量以及Tμ和Tg淋巴细胞数量与正常受试者实际无差异。抗原27、DR1和DR4被证明是HCMP的HLA标志物。与正常受试者和HCMP患者相比，观察到DCMP患者的Tμ和Tg细胞以及NK细胞数量明显减少。对DCMP患者HLA抗原分布的研究表明，DR1和DR4抗原的发生率更高。