Sergeev Iu V, Reznikov Iu P, Lobanova E V, Pimenova N S
Vestn Dermatol Venerol. 1989(4):4-7.
Eighty-eight patients with atopic dermatitis have been examined for the complementary proteins C3 (C3c), C3act., C4, C1inact. by radial immunodiffusion; in 36 of these patients anaphylatoxins C3a des Arg, C5a des Arg, and C4a des Arg have been radioimmunoassayed. Increased levels of C4a des Arg have been revealed in 50% of the examinees. C3a des Arg levels did not differ significantly from the reference values, and C5a des Arg level has been within the normal range in all the patients. C4a des Arg has been related to the severity of the skin inflammation and did not depend on the serum IgE content. C3 (C3c), C3act., C1inact. have been elevated and C4 reduced. These findings evidence activation of the complementary system in atopic dermatitis and indicate the role of anaphylatoxin C4a des Arg in the maintenance of the inflammatory reactions.
采用放射免疫扩散法对88例特应性皮炎患者检测了补体蛋白C3（C3c）、C3act.、C4、C1inact.；对其中36例患者采用放射免疫分析法检测了过敏毒素C3a des Arg、C5a des Arg和C4a des Arg。结果显示，50%的受检者C4a des Arg水平升高。C3a des Arg水平与参考值无显著差异，所有患者的C5a des Arg水平均在正常范围内。C4a des Arg与皮肤炎症的严重程度相关，且不依赖于血清IgE含量。C3（C3c）、C3act.、C1inact.升高而C4降低。这些结果证明特应性皮炎中补体系统被激活，并表明过敏毒素C4a des Arg在维持炎症反应中起作用。
