Stanford University, Department of Chemistry, 333 Campus Drive, Stanford, CA, 94305-4401, USA.
Department of Chemistry, King Fahd University of Petroleum and Minerals, P.O. 1509, Dhahran, 31261, Saudi Arabia.
Angew Chem Int Ed Engl. 2016 Oct 4;55(41):12807-11. doi: 10.1002/anie.201607204. Epub 2016 Sep 16.
We have developed nanoparticle-embedded paper-spray mass spectrometry for studying three types of heterogeneously catalyzed reactions: 1) Palladium-nanoparticle-catalyzed Suzuki cross-coupling reactions, 2) palladium- or silver-nanoparticle-catalyzed 4-nitrophenol reduction, and 3) gold-nanoparticle-catalyzed glucose oxidation. These reactions were almost instantaneous on the nanocatalyst-embedded paper, which subsequently transferred the transient intermediates and products to a mass spectrometer for their detection. This in situ method of capturing transient intermediates and products from heterogeneous catalysis is highly promising for investigating the mechanism of catalysis and rapidly screening catalytic activity under ambient conditions.
我们开发了一种纳米粒子嵌入的纸喷雾质谱技术，用于研究三种类型的异相催化反应：1）钯纳米粒子催化的 Suzuki 交叉偶联反应，2）钯或银纳米粒子催化的 4-硝基苯酚还原反应，以及 3）金纳米粒子催化的葡萄糖氧化反应。这些反应在纳米催化剂嵌入的纸上几乎是瞬间发生的，随后将瞬态中间体和产物转移到质谱仪中进行检测。这种从异相催化中捕获瞬态中间体和产物的原位方法对于研究催化机制和在环境条件下快速筛选催化活性具有很大的前景。
