Department of Microbiology and Infectious Diseases, Sydney South West Pathology Service, New South Wales Health Pathology, Sydney, New South Wales, Australia.
Molecular Medicine Research Group, School of Medicine, University of Western Sydney, Sydney, New South Wales, Australia.
Intern Med J. 2016 Sep;46(9):1011-6. doi: 10.1111/imj.13180.
Pyrexia of unknown origin (PUO) is a syndrome that has long tested the skills of physicians to achieve a diagnosis in affected patients. By definition, patients included in this syndrome will be more difficult to diagnose as they have already resisted classification during baseline investigations. Furthermore, investigation of PUO requires knowledge of many diseases across a range of clinical specialties, as well as knowledge of less commonly used investigative tools. As both society and medicine continue to change, the aetiology and epidemiology of the diseases that cause PUO also change. For these reasons, it is important for physicians to approach PUO in a logical manner, and for the causes and approach to PUO to be continuously reviewed. In this article, we review the aetiology of PUO and the diagnostic strategies that may be used to investigate it.
不明原因发热（PUO）是一种综合征，长期以来一直考验着医生的诊断技能，以确定受影响患者的诊断。根据定义，包括在该综合征中的患者将更难以诊断，因为他们在基线调查期间已经抗拒分类。此外，PUO 的调查需要了解许多临床专业的疾病，以及对使用较少的调查工具的了解。随着社会和医学的不断变化，引起 PUO 的疾病的病因和流行病学也在发生变化。出于这些原因，医生以逻辑的方式处理 PUO 非常重要，并且需要不断审查 PUO 的病因和方法。在本文中，我们回顾了 PUO 的病因以及可能用于调查的诊断策略。
