Pinto Graça, Silva Maria Daniela, Peddey Mark, Sillankorva Sanna, Azeredo Joana
CEB - Centre of Biological Engineering, LIBRO - Laboratório de Investigação em Biofilmes Rosário Oliveira, University of Minho, 4710-057 Braga, Portugal.
Mark Peddey Pty Ltd, 65 Glenhuntly Road, Elwood, VIC, Australia.
Future Microbiol. 2016 Oct;11:1359-1369. doi: 10.2217/fmb-2016-0081. Epub 2016 Sep 16.
The human periodontium health is commonly compromised by chronic inflammatory conditions and has become a major public health concern. Dental plaque, the precursor of periodontal disease, is a complex biofilm consisting mainly of bacteria, but also archaea, protozoa, fungi and viruses. Viruses that specifically infect bacteria - bacteriophages - are most common in the oral cavity. Despite this, their role in the progression of periodontal disease remains poorly explored. This review aims to summarize how bacteriophages interact with the oral microbiota, their ability to increase bacterial virulence and mediate the transfer of resistance genes and suggests how bacteriophages can be used as an alternative to the current periodontal disease therapies.
人类牙周健康通常会受到慢性炎症的影响，已成为一个主要的公共卫生问题。牙菌斑是牙周疾病的先兆，是一种复杂的生物膜，主要由细菌组成，但也包括古细菌、原生动物、真菌和病毒。专门感染细菌的病毒——噬菌体——在口腔中最为常见。尽管如此，它们在牙周疾病进展中的作用仍未得到充分研究。本综述旨在总结噬菌体如何与口腔微生物群相互作用，它们增加细菌毒力和介导耐药基因转移的能力，并提出噬菌体如何可作为当前牙周疾病治疗方法的替代方案。
