Burgos-Aceves Mario Alberto, Cohen Amit, Smith Yoav, Faggio Caterina
Centro de Investigaciones Biológicas de Noroeste, S.C., Mar Bermejo 195, Col. Playa Palo de Sta. Rita, La Paz BCS, 23090, México.
Genomic Data Analysis Unit, The Hebrew University of Jerusalem-Hadassah Medical School, P.O. Box 12272, Jerusalem 91120, Israel.
Fish Shellfish Immunol. 2016 Nov;58:42-49. doi: 10.1016/j.fsi.2016.09.006. Epub 2016 Sep 12.
Elucidating the mechanisms of estrogens-induced immunomodulation in teleost fish is of great importance due to the observed worldwide continuing decrease in pristine environments. However, little is know about the immunotoxicological consequences of exposure to these chemicals in fish, or of the mechanisms through which these effects are mediated. In this review, we summarize the results showing estrogens (natural or synthetic) acting through estrogen receptors and regulating specific target genes, also through microRNAs (miRNAs), leading to modulation of the immune functioning. The identification and characterization of miRNAs will provide new opportunities for functional genome research on teleost immune system and can also be useful when screening for novel molecule biomarkers for environmental pollution.
鉴于全球范围内原始环境持续减少的现状，阐明雌激素诱导硬骨鱼免疫调节的机制具有重要意义。然而，对于鱼类接触这些化学物质的免疫毒理学后果，以及介导这些效应的机制，我们知之甚少。在这篇综述中，我们总结了相关结果，表明雌激素（天然或合成）通过雌激素受体发挥作用并调节特定靶基因，也通过微小RNA（miRNA）发挥作用，从而导致免疫功能的调节。miRNA的鉴定和表征将为硬骨鱼免疫系统的功能基因组研究提供新的机会，并且在筛选环境污染的新型分子生物标志物时也可能有用。
