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Altered functional neuronal activity in neuropsychiatric lupus: A systematic review of the fMRI investigations.神经精神性狼疮中神经元功能活动的改变：功能磁共振成像研究的系统评价
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Neuropsychiatric systemic lupus erythematosus: pathogenesis and biomarkers.神经精神性狼疮：发病机制与生物标志物。
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Diminished white matter integrity in patients with systemic lupus erythematosus.系统性红斑狼疮患者的脑白质完整性降低。
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Efficacy of magnetic resonance diffusion tensor imaging and three-dimensional fiber tractography in the detection of clinical manifestations of central nervous system lupus.磁共振扩散张量成像及三维纤维束示踪技术在中枢神经系统狼疮临床表现检测中的效能
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Diagnosis and management of neuropsychiatric SLE.神经精神性狼疮的诊断与治疗。
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In vivo evaluation of brain damage in the course of systemic lupus erythematosus using magnetic resonance spectroscopy, perfusion-weighted and diffusion-tensor imaging.应用磁共振波谱、灌注加权成像和弥散张量成像评估系统性红斑狼疮患者脑损伤的体内研究。
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Functional neuronal network activity differs with cognitive dysfunction in childhood-onset systemic lupus erythematosus.儿童期起病的系统性红斑狼疮中，功能性神经网络活动随认知功能障碍而不同。
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The UCLA multimodal connectivity database: a web-based platform for brain connectivity matrix sharing and analysis.UCLA 多模态连接数据库：一个基于网络的大脑连接矩阵共享和分析平台。
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神经精神性系统性红斑狼疮患者的脑结构网络重组

Structural Brain Network Reorganization in Patients with Neuropsychiatric Systemic Lupus Erythematosus.

作者信息

Xu X, Hui E S, Mok M Y, Jian J, Lau C S, Mak H K F

机构信息

From the Department of Diagnostic Radiology (X.X., E.S.H., H.K.F.M.).

From the Department of Diagnostic Radiology (X.X., E.S.H., H.K.F.M.)

出版信息

AJNR Am J Neuroradiol. 2017 Jan;38(1):64-70. doi: 10.3174/ajnr.A4947. Epub 2016 Sep 15.

DOI:10.3174/ajnr.A4947
PMID:27633804
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7963675/
Abstract

BACKGROUND AND PURPOSE

Patients with neuropsychiatric systemic lupus erythematosus have worse outcomes compared with those with systemic lupus erythematosus. A better understanding of the mechanisms of neuropsychiatric systemic lupus erythematosus could potentially improve diagnosis and management. The goal of this study was to investigate the differences in the structural brain network of patients with neuropsychiatric systemic lupus erythematosus compared with patients with systemic lupus erythematosus by using brain connectivity analysis.

MATERIALS AND METHODS

We recruited 20 subjects for each patient cohort and age-matched healthy controls. The topology and efficiency of the network and the characteristics of various brain hubs were investigated by using brain connectivity analysis of diffusion MR imaging data.

RESULTS

There were more extensive reorganizations in the structural brain network of patients with neuropsychiatric systemic lupus erythematosus than in patients with systemic lupus erythematosus. For example, the network of the former had significantly decreased clustering coefficient and local efficiency. They also had significantly lower nodal efficiency in the superior temporal gyrus (P = .046) and middle temporal gyrus (P = .041).

CONCLUSIONS

Our results hint at a plausible relationship between the neuropsychiatric symptoms and reorganization of the structural brain network of patients with systemic lupus erythematosus. Brain connectivity analysis may be a potential tool to subtype these patients.

摘要

背景与目的

与系统性红斑狼疮患者相比，神经精神性系统性红斑狼疮患者的预后更差。更好地了解神经精神性系统性红斑狼疮的发病机制可能会改善其诊断和治疗。本研究的目的是通过脑连接性分析，研究神经精神性系统性红斑狼疮患者与系统性红斑狼疮患者在脑结构网络上的差异。

材料与方法

我们为每个患者队列和年龄匹配的健康对照组招募了20名受试者。通过对扩散磁共振成像数据进行脑连接性分析，研究网络的拓扑结构和效率以及各个脑枢纽的特征。

结果

与系统性红斑狼疮患者相比，神经精神性系统性红斑狼疮患者的脑结构网络重组更为广泛。例如，前者的网络聚类系数和局部效率显著降低。他们在颞上回（P = 0.046）和颞中回（P = 0.041）的节点效率也显著较低。

结论

我们的结果提示系统性红斑狼疮患者的神经精神症状与脑结构网络重组之间可能存在合理的关系。脑连接性分析可能是对这些患者进行亚型分类的潜在工具。