Calvo-Maroto Ana M, Esteve-Taboada Jose J, Domínguez-Vicent Alberto, Pérez-Cambrodí Rafael J, Cerviño Alejandro
a Optometry Research Group, Department of Optics & Optometry & Vision Sciences , University of Valencia , Valencia , Spain.
b Department of Ophthalmology , Oftalmar, Medimar International Hospital , Alicante , Spain.
Expert Rev Med Devices. 2016 Oct;13(10):965-978. doi: 10.1080/17434440.2016.1236678. Epub 2016 Sep 27.
Fundus autofluorescence (FAF) is a noninvasive imaging method to detect fundus endogenous fluorophores, mainly lipofuscin located in the retinal pigment epithelium (RPE). The FAF provides information about lipofuscin distribution and RPE health, and consequently an increased accumulation of lipofuscin has been correlated with ageing and development of certain retinal conditions. Areas covered: An exhaustive literature search in MEDLINE (via OVID) and PUBMED for articles related to ocular FAF in retinal diseases and different devices used for acquiring FAF imaging was conducted. Expert commentary: This review aims to show an overview about autofluorescence in the RPE and the main devices used for acquiring these FAF images. The knowledge of differences in the optical principles, acquisition images and the image post-processing between confocal scanning laser ophthalmoscopy and modified conventional fundus camera will improve the FAF images interpretation when are used as a complementary diagnosis and monitoring tool of retinal diseases.
眼底自发荧光（FAF）是一种用于检测眼底内源性荧光团的非侵入性成像方法，主要是位于视网膜色素上皮（RPE）中的脂褐素。FAF可提供有关脂褐素分布和RPE健康状况的信息，因此脂褐素积累增加与某些视网膜疾病的衰老和发展相关。涵盖领域：通过MEDLINE（经由OVID）和PUBMED对与视网膜疾病中眼部FAF以及用于获取FAF成像的不同设备相关的文章进行了详尽的文献检索。专家评论：本综述旨在展示关于RPE中自发荧光以及用于获取这些FAF图像的主要设备的概述。了解共焦扫描激光眼科显微镜和改良传统眼底照相机在光学原理、采集图像和图像后处理方面的差异，将有助于在将其用作视网膜疾病的辅助诊断和监测工具时更好地解读FAF图像。
