Jones Carolyn E, Monfils Marie-H
Department of Psychology, The University of Texas at Austin, Austin, Texas 78712-1043, USA.
Department of Psychology, The University of Texas at Austin, Austin, Texas 78712-1043, USA
Learn Mem. 2016 Sep 15;23(10):567-75. doi: 10.1101/lm.043281.116. Print 2016 Oct.
Traumatic experiences early in life can contribute to the development of mood and anxiety disorders that manifest during adolescence and young adulthood. In young rats exposed to acute fear or stress, alterations in neural development can lead to enduring behavioral abnormalities. Here, we used a modified extinction intervention (retrieval+extinction) during late adolescence (post-natal day 45 [p45]), in rats, to target auditory Pavlovian fear associations acquired as juveniles (p17 and p25). The effects of adolescent intervention were examined by assessing freezing as adults during both fear reacquisition and social transmission of fear from a cagemate. Rats underwent testing or training at three time points across development: juvenile (p17 or p25), adolescent (p45), and adult (p100). Retrieval+extinction during late adolescence prevented social reinstatement and recovery over time of fears initially acquired as juveniles (p17 and p25, respectively). Adolescence was the only time point tested here where retrieval+extinction prevented fear recall of associations acquired 20+ days earlier.
早年的创伤经历可能会导致在青春期和青年期出现的情绪和焦虑障碍。在暴露于急性恐惧或应激的幼鼠中，神经发育的改变会导致持久的行为异常。在此，我们在大鼠青春期后期（出生后第45天[p45]）使用了一种改良的消退干预（回忆+消退），以针对幼年（p17和p25）时获得的听觉巴甫洛夫式恐惧关联。通过在恐惧重新习得和来自同笼伙伴的恐惧社会传递过程中评估成年大鼠的僵住情况，来检验青春期干预的效果。大鼠在发育过程中的三个时间点接受测试或训练：幼年（p17或p25）、青春期（p45）和成年期（p100）。青春期后期的回忆+消退可防止最初在幼年（分别为p17和p25）时获得的恐惧随着时间的推移而出现社会恢复和重新出现。青春期是此处测试的唯一时间点，回忆+消退可防止对20多天前获得的关联的恐惧回忆。
