Institute for Mental Health Research, The University of Texas at Austin, Austin, TX, USA.
Department of Psychology, The University of Texas at Austin, Austin, TX, USA.
Philos Trans R Soc Lond B Biol Sci. 2018 Mar 19;373(1742). doi: 10.1098/rstb.2017.0035.
Fear conditioning is widely employed to examine the mechanisms that underlie dysregulations of the fear system. Various manipulations are often used following fear acquisition to attenuate fear memories. In rodent studies, freezing is often the main output measure to quantify 'fear'. Here, we developed data-driven criteria for defining a standard benchmark that indicates remission from conditioned fear and for identifying subgroups with differential treatment responses. These analyses will enable a better understanding of individual differences in treatment responding.This article is part of a discussion meeting issue 'Of mice and mental health: facilitating dialogue between basic and clinical neuroscientists'.
恐惧条件反射被广泛用于研究恐惧系统失调的机制。在获得恐惧后，通常会采用各种操作来减弱恐惧记忆。在啮齿动物研究中，冻结通常是量化“恐惧”的主要输出测量指标。在这里，我们制定了基于数据的标准基准定义标准，以表明条件性恐惧的缓解，并识别具有不同治疗反应的亚组。这些分析将有助于更好地理解治疗反应中的个体差异。本文是“老鼠和精神健康：促进基础和临床神经科学家之间的对话”专题讨论的一部分。
