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左旋咪唑/苯并咪唑耐药性捻转血矛线虫幼虫的运动反应

Motility response of levamisole/benzimidazole-resistant Haemonchus contortus larvae.

作者信息

Coles G C, Folz S D, Tritschler J P

机构信息

Department of Zoology, University of Massachusetts, Amherst 01003.

出版信息

Vet Parasitol. 1989 Jun;31(3-4):253-7. doi: 10.1016/0304-4017(89)90074-5.

Abstract

Electronic measurements of the motility of third stage larvae of a susceptible and a levamisole/benzimidazole-resistant strain of Haemonchus contortus were made after incubation in solutions of anthelmintics for 24 h. Results confirmed the resistance to benzimidazoles, but failed to show differences in response to levamisole. Visual observations of paralysis of first and third stage larvae in solutions of levamisole also failed to show significant differences between the two strains. The tests as conducted failed to demonstrate levamisole resistance, suggesting that nematode strains may vary in their mechanisms of resistance to levamisole.

摘要

将捻转血矛线虫的一个敏感品系和一个对左旋咪唑/苯并咪唑耐药的品系的三期幼虫在驱虫药溶液中孵育24小时后,对其运动性进行了电子测量。结果证实了对苯并咪唑的耐药性,但未显示出对左旋咪唑反应的差异。对左旋咪唑溶液中一期和三期幼虫麻痹情况的肉眼观察也未显示出两个品系之间存在显著差异。所进行的试验未能证明左旋咪唑耐药性,这表明线虫品系对左旋咪唑的耐药机制可能有所不同。

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