INMED, INSERM U901, Aix-Marseille Université, Marseille, France.
Science. 2016 Sep 16;353(6305):1280-3. doi: 10.1126/science.aaf3319.
The chained activation of neuronal assemblies is thought to support major cognitive processes, including memory. In the hippocampus, this is observed during population bursts often associated with sharp-wave ripples, in the form of an ordered reactivation of neurons. However, the organization and lifetime of these assemblies remain unknown. We used calcium imaging to map patterns of synchronous neuronal activation in the CA1 region of awake mice during runs on a treadmill. The patterns were composed of the recurring activation of anatomically intermingled, but functionally orthogonal, assemblies. These assemblies reactivated discrete temporal segments of neuronal sequences observed during runs and could be stable across consecutive days. A binding of these assemblies into longer chains revealed temporally ordered replay. These modules may represent the default building blocks for encoding or retrieving experience.
神经元集合的连锁激活被认为支持主要的认知过程，包括记忆。在海马体中，这是在与尖波涟漪相关的群体爆发期间观察到的，其形式是神经元的有序再激活。然而，这些集合的组织和寿命仍然未知。我们使用钙成像技术在清醒小鼠在跑步机上跑步时映射 CA1 区域中同步神经元激活的模式。这些模式由反复激活解剖上混合但功能正交的集合组成。这些集合可以重新激活在跑步过程中观察到的离散的神经元序列的时间片段，并且可以在连续的几天内保持稳定。将这些集合绑定成更长的链揭示了时间有序的重播。这些模块可能代表编码或检索经验的默认构建块。
