Brain Research Centre, Department of Neuroscience, School of Life Sciences, Southern University of Science and Technology, Shenzhen, 518055, China.
Shenzhen Key Laboratory of Precision Diagnosis and Treatment of Depression, Shenzhen-Hong Kong Institute of Brain Science, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Nat Commun. 2024 Nov 21;15(1):10075. doi: 10.1038/s41467-024-54320-z.
A proportion of hippocampal CA1 neurons function as place cells from the onset of navigation, which are referred to as early place cells. It is not clear whether this subset of neurons is predisposed to become place cells during early stages, or if all neurons have this potential. Here, we longitudinally imaged the activity of CA1 neurons in developing male rats during navigation with both one-photon and two-photon microscopy. Our results suggested that a largely consistent population of cells functioned as early place cells, demonstrating higher spatial coding abilities across environments and a tendency to form more synchronous cell assemblies. Early place cells were present in both deep and superficial layers of CA1. Cells in the deep layer exhibited greater synchrony than those in the superficial layer during early ages. These results support the theory that an initial cognitive map is primarily shaped by a predetermined set of hippocampal cells.
一部分海马 CA1 神经元从导航开始就充当位置细胞，这些细胞被称为早期位置细胞。目前尚不清楚这一小部分神经元是否在早期就有倾向成为位置细胞，或者所有神经元都有这种潜力。在这里，我们使用单光子和双光子显微镜对发育中的雄性大鼠在导航过程中 CA1 神经元的活动进行了纵向成像。我们的结果表明，一大群细胞作为早期位置细胞发挥作用，表现出跨环境更高的空间编码能力和形成更同步细胞集合的趋势。早期位置细胞存在于 CA1 的深层和浅层。在早期，深层的细胞比浅层的细胞表现出更大的同步性。这些结果支持了这样一种理论，即最初的认知地图主要是由一组预先确定的海马细胞形成的。
