The University of Texas M.D. Anderson Cancer Center, Houston, Texas.
Cancer Res. 2016 Oct 1;76(19):5597-5601. doi: 10.1158/0008-5472.CAN-16-0431. Epub 2016 Sep 15.
There is increasing evidence supporting a role for B cells in tumor immunology. Paraneoplastic syndromes occurring before a cancer diagnosis have pointed to the potential for harnessing the humoral immune response for early cancer detection. The presence of tumor-infiltrating B lymphocytes has been linked to a favorable clinical outcome in many types of cancers. However, B cells represent a heterogeneous population with functionally distinct subsets, and the balance among subtypes impacts tumor development. Here, we review recent findings related to B cells and to the humoral immune response in cancer and their translational significance. Cancer Res; 76(19); 5597-601. ©2016 AACR.
越来越多的证据支持 B 细胞在肿瘤免疫学中的作用。在癌症诊断之前出现的副肿瘤综合征表明，有可能利用体液免疫反应进行早期癌症检测。在许多类型的癌症中，肿瘤浸润 B 淋巴细胞的存在与良好的临床结果相关。然而，B 细胞是一个具有不同功能亚群的异质性群体，亚群之间的平衡影响肿瘤的发展。在这里，我们综述了与癌症中的 B 细胞和体液免疫反应及其转化意义相关的最新发现。Cancer Res; 76(19); 5597-601. ©2016 AACR.
