Saji H, Maruya E, Fujii H, Maekawa T, Akiyama Y, Matsuura T, Hosoi T
Department of Research, Kyoto Red Cross Blood Center, Japan.
Vox Sang. 1989;56(4):283-7. doi: 10.1111/j.1423-0410.1989.tb02043.x.
Siba, a new platelet-specific alloantigen involved in a case of platelet transfusion refractoriness is reported. The IgG platelet alloantibody was detected in a multiply transfused patient of Japanese extraction (Sib), by the presence of HLA antibodies. After transfusion of HLA-compatible platelets, the patient suffered from refractoriness. Adsorption studies with pooled lymphocytes showed that the serum contained anti-platelet activity. Family studies indicate that Siba is inherited as an autosomal codominant trait and separate from HLA and Baka. As of this report, segregation from Zw(PlA) and Yuk (Pen) antigen systems have not yet been determined. The gene frequency of Siba in the Japanese population is estimated to be 0.136.
报道了一种与血小板输注无效病例相关的新的血小板特异性同种抗原Siba。在一名多次输血的日本裔患者（Sib）中，通过检测到HLA抗体，发现了IgG血小板同种抗体。输注HLA相容的血小板后，该患者出现了输注无效。用混合淋巴细胞进行的吸附研究表明，血清中含有抗血小板活性。家系研究表明，Siba作为常染色体共显性性状遗传，与HLA和Baka无关。截至本报告，尚未确定其与Zw(PlA)和Yuk (Pen)抗原系统的分离情况。日本人群中Siba的基因频率估计为0.136。
