Department of Pathology, Dartmouth-Hitchcock Medical Center and Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire.
Department of Anatomic Pathology, University of Washington School of Medicine, Seattle, Washington.
Ann N Y Acad Sci. 2016 Oct;1381(1):133-138. doi: 10.1111/nyas.13260. Epub 2016 Sep 16.
The clinical significance of lymphocytic esophagitis (LyE), which is characterized by the prominence of peripapillary intraepithelial lymphocytes (IELs) without significant granulocytosis, remains poorly understood. During the last few years, plausible clinical correlates and novel approaches for stratification of LyE have started to emerge. Association with Crohn's disease has been established in children, but is not observed in adults. In adults, the form of LyE showing CD4 -predominant IELs has been recently found to be associated with non-achalasia primary motility abnormalities. GERD is another possible association. The most common clinical manifestations of adult LyE are dysphagia and normal endoscopic appearance of the esophagus. LyE should be reported by pathologists in order to distinguish it from its mimics, such as eosinophilic esophagitis, and to assist in directing the next steps in evaluation for known associated diseases, such as Crohn's disease or motility disorders.
淋巴细胞性食管炎（LyE）的临床意义尚不清楚，其特征是神经周围上皮内淋巴细胞（IEL）明显增多，而粒细胞增多不明显。在过去几年中，与 LyE 相关的合理临床相关性和新型分层方法开始出现。在儿童中已确定与克罗恩病有关，但在成人中则没有观察到。在成人中，最近发现 CD4 细胞为主的 IEL 表现的 LyE 与非贲门失弛缓症原发性运动障碍有关。GERD 是另一种可能的关联。成人 LyE 最常见的临床表现是吞咽困难和食管内镜正常外观。病理学家应报告 LyE，以将其与嗜酸性食管炎等类似疾病区分开来，并有助于为已知相关疾病（如克罗恩病或运动障碍）的评估指导下一步措施。
