Bukharovich M N, Mussa M, Shlopov V G, Shevchenko T I
Vestn Dermatol Venerol. 1989(4):38-42.
Comprehensive examinations of dermal morphology and function, carried out in 50 patients suffering from psoriasis, have revealed manifest hypoxia, depression of the intramitochondrial energy production, reduction of the cellular synthetic potency, increased protein catabolism, impaired transcapillary transport and vascular and tissue permeability, immediate and delayed type hypersensitivity local immune reactions. Basing on these findings, the authors have developed a new effective method for multiple modality treatment of psoriasis patients. The new scheme includes, besides the routine modalities (sedative and lipotropic drug, vitamins, UV irradiation, diets, ointments), subcutaneous injections of oxygen into the large foci (200 ml daily, 12-18 injections per course, alternating the injection sites) and oral intake of copper sulfate and reduced iron (3 times daily after meals for 20-30 days). The study has involved 112 patients with psoriasis (61 patients in the test group and 51 in the reference one). Clinical and morphologic examinations have demonstrated the advantages of the new method: clinical remission has occurred 1.8 times more often, the length of treatment has been cut by 7 days, an earlier and more complete recovery of the morphofunctional characteristics of the dermis has been achieved.
对50例银屑病患者进行的皮肤形态和功能综合检查发现，存在明显的缺氧、线粒体能量产生降低、细胞合成能力下降、蛋白质分解代谢增加、毛细血管转运及血管和组织通透性受损、速发型和迟发型超敏局部免疫反应。基于这些发现，作者开发了一种新的有效方法用于银屑病患者的多模式治疗。新方案除了常规模式（镇静和促脂药物、维生素、紫外线照射、饮食、药膏）外，还包括向大病灶皮下注射氧气（每天200毫升，每个疗程注射12 - 18次，交替注射部位）以及口服硫酸铜和还原铁（饭后每天3次，持续20 - 30天）。该研究纳入了112例银屑病患者（试验组61例，参照组51例）。临床和形态学检查证明了新方法的优势：临床缓解的发生频率提高了1.8倍，治疗时间缩短了7天，真皮的形态功能特征更早且更完全地恢复。
