Nowak R, Balabanova S, Odenwäller U
Abteilung Rechtsmedizin, Universität Ulm, Bundesrepublik Deutschland.
Z Rechtsmed. 1989;102(7):445-50. doi: 10.1007/BF00204075.
This study investigated the transfer of cocaine and its metabolites from plasma into the cerebrospinal fluid. The concentration of cocaine and its metabolites in plasma and cerebrospinal fluid was determined by radioimmunoassay because this method only, the sum of the drug and metabolites restored. In sheeps a sublethal cocaine hydrochloride dose (2,4 mg/kg b. wt.) was administered intraarterial daily for up to 8 days. In the first hours after administration the concentration of cocaine in cerebrospinal fluid was low. It is supposed that a barrier against the transport of cocaine from blood into cerebrospinal fluid exists. After intrathecal administration a delay of transport could from CSF to blood not be seen.
本研究调查了可卡因及其代谢产物从血浆向脑脊液的转移情况。采用放射免疫分析法测定血浆和脑脊液中可卡因及其代谢产物的浓度，因为只有这种方法能检测到药物及其代谢产物的总量。在绵羊身上，每天经动脉给予亚致死剂量的盐酸可卡因（2.4毫克/千克体重），持续8天。给药后的最初几个小时，脑脊液中可卡因的浓度较低。据推测，存在一种阻止可卡因从血液进入脑脊液的屏障。鞘内给药后，未观察到从脑脊液到血液的转运延迟。
