Nowak R, Balabanova S, Brunner H, Homoki J, Bürger B, Reinhardt G
Department of Forensic Medicine, University of Ulm, Federal Republic of Germany.
Z Rechtsmed. 1988;99(4):235-40. doi: 10.1007/BF00204433.
The deposition of cocaine in tissue after lethal administration to sheep was investigated. In addition, the presence of cocaine in tissue obtained from sheep treated for 30 days with a sublethal dose (2.4 mg/kg b.wt.) after 1-day, 1-week, or 1-month withdrawal was studied. The determination of cocaine was performed by radioimmunoassay. The concentrations measured represent the sum of cocaine and its metabolites. The presence of cocaine was also qualitatively proven by gas chromatography/mass spectrometry. After a lethal dose administration cocaine was found in all investigated organs. The highest concentrations were present in liver, bile, and kidney. In tissue obtained from the sheep treated daily with a sublethal dose and killed after 1-week withdrawal, the concentrations found were significantly lower. After 1-month withdrawal, cocaine was not to be discovered in tissue.
研究了对绵羊致死给药后可卡因在组织中的沉积情况。此外，还研究了用亚致死剂量（2.4毫克/千克体重）处理30天的绵羊在停药1天、1周或1个月后所取组织中可卡因的存在情况。可卡因的测定采用放射免疫分析法。所测浓度代表可卡因及其代谢物的总和。可卡因的存在也通过气相色谱/质谱法定性证实。给予致死剂量后，在所有研究的器官中均发现了可卡因。最高浓度存在于肝脏、胆汁和肾脏中。在每天用亚致死剂量处理并在停药1周后处死的绵羊所取组织中，所发现的浓度明显较低。停药1个月后，在组织中未发现可卡因。
