Winkler Ethan A, Minter Daniel, Yue John K, Manley Geoffrey T
Brain and Spinal Injury Center, San Francisco General Hospital, 1001 Potrero Avenue, Building 1, Room 101, San Francisco, CA 94110, USA; Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Avenue, M779, San Francisco, CA 94143, USA.
Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Avenue, M779, San Francisco, CA 94143, USA.
Neurosurg Clin N Am. 2016 Oct;27(4):473-88. doi: 10.1016/j.nec.2016.05.008.
Traumatic brain injury is a heterogeneous disorder resulting from an external force applied to the head. The development of cerebral edema plays a central role in the evolution of injury following brain trauma and is closely associated with neurologic outcomes. Recent advances in the understanding of the molecular and cellular pathways contributing to the posttraumatic development of cerebral edema have led to the identification of multiple prospective therapeutic targets. The authors summarize the pathogenic mechanisms underlying cerebral edema and highlight the molecular pathways that may be therapeutically targeted to mitigate cerebral edema and associated sequelae following traumatic brain injury.
创伤性脑损伤是一种由头部受到外力作用导致的异质性疾病。脑水肿的形成在脑外伤后损伤的进展中起核心作用，并且与神经学预后密切相关。在理解促成创伤后脑水肿发生的分子和细胞途径方面的最新进展，已导致确定了多个潜在的治疗靶点。作者总结了脑水肿的发病机制，并着重介绍了可能成为治疗靶点的分子途径，以减轻创伤性脑损伤后的脑水肿及相关后遗症。
