Pant Meghna, Bal Naresh C, Periasamy Muthu
Department of Physiology and Cell Biology, Ohio State University, Columbus, OH, USA.
Sanford Burnham Medical Research Institute at Lake Nona, Orlando, FL, USA; School of Biotechnology, KIIT University, Bhubaneswar, Odisha, India.
Trends Endocrinol Metab. 2016 Dec;27(12):881-892. doi: 10.1016/j.tem.2016.08.006. Epub 2016 Sep 13.
Skeletal muscle constitutes ∼40% of body mass and has the capacity to play a major role as thermogenic, metabolic, and endocrine organ. In addition to shivering, muscle also contributes to nonshivering thermogenesis via futile sarcoplasmic/endoplasmic reticulum Ca ATPase (SERCA) activity. Sarcolipin (SLN), a regulator of SERCA activity in muscle, plays an important role in regulating muscle thermogenesis and metabolism. Uncoupling of SERCA by SLN increases ATP hydrolysis and heat production, and contributes to temperature homeostasis. SLN also affects whole-body metabolism and weight gain in mice, and is upregulated in various muscle diseases including muscular dystrophy, suggesting a role for SLN during increased metabolic demand. In this review we also highlight the physiological roles of skeletal muscle beyond contraction.
骨骼肌约占体重的40%，有能力作为产热、代谢和内分泌器官发挥主要作用。除了颤抖之外，肌肉还通过无效的肌浆网/内质网Ca-ATP酶（SERCA）活性促进非颤抖性产热。肌浆脂蛋白（SLN）是肌肉中SERCA活性的调节剂，在调节肌肉产热和代谢中起重要作用。SLN使SERCA解偶联会增加ATP水解和产热，并有助于维持体温平衡。SLN还影响小鼠的全身代谢和体重增加，并且在包括肌肉萎缩症在内的各种肌肉疾病中上调，这表明SLN在代谢需求增加时发挥作用。在这篇综述中，我们还强调了骨骼肌在收缩之外的生理作用。
