Lintner F, Hertelendy F, Zsolnay B
2nd Department of Obstetrics and Gynaecology, Semmelweis University Medical School, Budapest, Hungary.
Acta Chir Hung. 1989;30(2):109-17.
Uterine contractions are largely regulated by steroid hormones. The receptors which are important from the point of view of uterine contractions (such as oxytocin, alpha- and beta-adrenergics) are also influenced by steroid hormones. In this paper the regulation by steroids of PG2 alpha receptors was studied in vivo. Due to ovariectomy, the concentration of PG2 alpha decreased significantly in rats without a change in affinity. As a result of in vivo progesterone treatment, the PG2 alpha receptor concentration decreased to its third as compared to that of the ovariectomized control also without a change in affinity. PG2 alpha receptor concentration was not changed by in vivo estrogen treatment in comparison to that of the ovariectomized control but a high-affinity, low-capacity binding-site appeared. Our experiments revealed the in vivo regulation by steroid hormones of the PGW2 alpha receptors of the rat myometrium.
子宫收缩很大程度上受甾体激素调节。从子宫收缩角度来看很重要的受体（如催产素、α和β肾上腺素能受体）也受甾体激素影响。本文在体内研究了甾体激素对PG2α受体的调节作用。由于卵巢切除，大鼠体内PG2α浓度显著降低，亲和力不变。体内给予孕酮后，与卵巢切除对照相比，PG2α受体浓度降至其三分之一，亲和力也不变。与卵巢切除对照相比，体内给予雌激素后PG2α受体浓度未改变，但出现了一个高亲和力、低容量的结合位点。我们的实验揭示了甾体激素在体内对大鼠子宫肌层PGW2α受体的调节作用。
